NR ABWT
AU Brown,P.; Cathala,F.; Sadowsky,D.; Gajdusek,D.C.
TI Creutzfeldt-Jakob disease in France: II. Clinical characteristics of 124 consecutive verified cases during the decade 1968-1977.
QU Annals of Neurology 1979 Nov; 6(5): 430-7
PT journal article
AB One hundred twenty-four consecutive cases of Creutzfeldt-Jakob disease (CJD) in France, verified by biopsy or autopsy between 1968 and 1977, were analyzed with respect to their clinical characteristics. The series comprised equal numbers of men and women, with the most frequent age at onset being 60 to 64 years and the most frequent duration, two to three months. A prodromal illness was observed in more than one-third of the patients. Clinical presentations and symptom frequencies are tabulated, and a multifactor analysis has been performed to obtain those combinations of symptoms and signs which occurred at least as often as the triad of dementia, myoclonus, and a positive electroencephalogram. Two groups of atypical cases are also emphasized: one with sudden, strokelike presentation and rapidly evolving illness of less than 2 months' duration, and the other with a long clinical course of between 2 and 10 years.
IN Zwischen 1968 und 1977 wurden in Frankreich 124 Fälle von pathologisch bestätigter Creutzfeldt-Jakob-Krankheit registriert. Männer und Frauen waren gleich häufig betroffen. Die Krankheit brach meistens im Alter von 60-64 Jahren auf und dauerte meistens 2-3 Monate. Bei einem Drittel der Fälle gab es ein Vorläuferstadium. Es gab auch Fälle mit ganz plötzlichem Einsetzen der Symptome und Tod nach weniger als 2 Monaten und andere Fälle, bei denen sich die Krankheitsphase über 2-10 Jahre hinzog.
MH Age Factors; Aged; Creutzfeldt-Jakob Syndrome/diagnosis/*epidemiology/genetics; Factor Analysis, Statistical; Female; France; Human; Male; Middle Age; Sex Factors
SP englisch
PO USA