NR ABWI
AU Brown,P.; Cathala,F.; Labauge,R.; Pages,M.; Alary,J.C.; Baron,H.
TI Epidemiologic implications of Creutzfeldt-Jakob disease in a 19 year-old girl
QU European Journal of Epidemiology 1985 Mar; 1(1): 42-7
PT journal article
AB A histopathologically-verified, clinically typical case of Creutzfeldt-Jakob disease (CJD) is described in a 19 year-old girl. Only 3 previous cases of CJD have been reported in adolescents, and one of these was iatrogenically transmitted, while another was familial. Epidemiologic investigation of the present case excluded a familial component, and provided no evidence for iatrogenic or natural case-to-case transmission, or of other environmental sources of viral contamination. Young patients such as this one serve to emphasize the obscurity that still surrounds the epidemiology of CJD, and invite serious reconsideration of the possibilities of transmission by undetected virus carriers, or of the agent as a natural resident of human cells, replication of which might be triggered by non-infective (e.g., traumatic or mutational) environmental events.
IN Eine 19-jährige Französin starb 1982 nach typischen klinischem Verlauf, histopathologisch gesichert an der Creutzfeldt-Jakob-Krankheit. Eine erbliche Belastung oder eine als Ursache in Frage kommende medizinsche Maßnahme wurde nicht festgestellt.
MH Adult; Case Report; Creutzfeldt-Jakob Syndrome/*etiology/pathology/transmission; Female; France; Human; Temporal Lobe/*pathology
AD Paul Brown (pwb@codon.nih.gov), Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
SP englisch
PO Italien