NR ABWB
AU Brown,P.; Cathala,F.; Raubertas,R.F.; Gajdusek,D.C.; Castaigne,P.
TI The epidemiology of Creutzfeldt-Jakob disease: Conclusion of a 15-year investigation in France and review of the world literature.
QU Neurology 1987 Jun; 37(6): 895-904
PT journal article
AB During the 15-year period 1968-1982, a total of 329 patients dying of Creutzfeldt-Jakob disease (CJD) were identified in continental France. Annual mortality rates stabilized at 0.5 to 0.6 cases per million (1.1 to 1.2 cases per million in Paris). Six percent of cases were familial. Although the frequency of CJD was related to population density, no contacts could be established among the great majority of patients. No association with socioeconomic factors, preceding trauma or surgery (excepting one iatrogenic neurosurgical case), or exposure to animal sources of infection was identified. Evidence from this and other epidemiologic studies suggests that CJD is a minimally contagious disease that may be principally acquired in early life from presymptomatic patients, asymptomatic carriers, or chance contamination by environmental sources. It is possible that CJD could also occur sporadically as a noncontagious disease by a mechanism akin to oncogenes in carcinogenesis.
MH Adolescent; Adult; Aged; Animal; Child; Child, Preschool; Creutzfeldt-Jakob Syndrome/*epidemiology/etiology/transmission; Female; France; Human; Male; Middle Age; Scrapie/transmission
AD Paul Brown (pwb@codon.nih.gov), Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
SP englisch
PO USA
OR Prion-Krankheiten 2