NR ABPP
AU Brandel,J.P.; Beaudry,P.; Delasnerie-Laupretre,N.; Laplanche,J.L.
TI [Creutzfeldt-Jakob disease: diagnostic value of protein 14-3-3 and neuronal specific enolase assay in cerebrospinal fluid]
OT Maladie de Creutzfeldt-Jakob: valeur diagnostique de la detection de la proteine 14-3-3 et du dosage de la NSE dans le liquide cephalo-rachidien.
QU Revue Neurologique 1999 Feb; 155(2): 148-51
PT journal article
AB We studied the diagnostic value of detecting protein 14-3-3 and of assaying neuronal specific enolase (NSE) in the cerebrospinal fluid of 150 patients with suspected sporadic Creutzfeldt-Jakob disease registered in an epidemiology research program between 1991 and 1996. Sensitivity and specificity of these two tests were high. This study confirms results reported earlier and authorizes a new definition of Creutzfeldt-Jakob disease which gives protein 14-3-3 the same diagnostic value as EEG recordings for classifying sporadic cases.
MH Cerebrospinal Fluid Proteins/*analysis; Creutzfeldt-Jakob Syndrome/*cerebrospinal fluid/diagnosis/*enzymology; Electroencephalography; English Abstract; Epilepsies, Myoclonic/diagnosis; Human; Phosphopyruvate Hydratase/*metabolism; Predictive Value of Tests; Proteins/*analysis; Retrospective Studies
AD INSERM Unite 360, Hopital de la Salpetriere, Paris.
SP französisch
PO Frankreich