NR ABNX
AU Boudinot,E.; Tremblay,P.; Champagnat,J.; Foutz,A.S.
TI Respiratory function in mice lacking or overexpressing the prion protein
QU Neuroscience Letters 2002 Apr 26; 323(2): 89-92
PT journal article
AB We investigated a possible involvement of the prion protein in ventilatory control in four groups of mice, those deficient for the prion protein (PrPc), those overexpressing the prion protein, and two groups of genetically and age-matched controls. Ventilatory patterns of unrestrained mice were measured in a whole-body plethysmograph. Between each genotype and its control, we compared ventilation at rest and the ventilatory response to moderate hypoxia (10-12% O2), hyperoxia and hyperoxic hypercapnia. Mice lacking or overexpressing PrPc and their respective controls showed similar ventilatory patterns at rest and similar chemosensory responses when awake and under urethane anesthesia. Our results do not support the view that PrPc may play any significant role in basal ventilation or in the chemosensory ventilatory control of adult mice.
MH Animal; Comparative Study; Female; Hypoxia, Brain/genetics/metabolism; Male; Mice; Mice, Knockout; Mice, Transgenic; Phosphoprotein Phosphatase/*biosynthesis/deficiency/*genetics; Pulmonary Ventilation/*genetics/physiology; Support, Non-U.S. Gov't
AD Neurobiologie Genetique et Integrative, Institut de Neurobiologie Alfred Fessard, C.N.R.S., F-91198 Gif-sur-Yvette Cedex, France.
SP englisch
PO Irland
OR Prion-Krankheiten 2