NR ABLC
AU Bogumil,T.; Beuche,W.; Schindler,C.; Schachenmayr,W.; Kretzschmar,H.A.
TI [Creutzfeldt-Jakob disease. Report of a case with an unusually long course and immunohistochemical localization of the prion protein and overview of current information]
OT Die Creutzfeldt-Jakob-Krankheit. Bericht über einen Fall mit ungewöhnlich langem Verlauf und immunhistochemischer Lokalisierung des Prionproteins sowie Überblick über den heutigen Wissensstand.
QU Der Nervenarzt 1994 Dec; 65(12): 865-73
PT journal article; review; review, tutorial
AB The human spongiform encephalopathies are a group of neurodegenerative disorders of unknown origin. They comprise a group of horizontally transmissible and genetically determined diseases. We present here a case of Creutzfeldt-Jakob disease with an unusually long clinical course, in which the prion protein was localized immunohistochemically. The generally accepted hypothesis on the pathogenesis of these diseases is the so-called 'prion-hypothesis'. The implications of this hypothesis are discussed and a short review of the literature is given.
ZR 89
MH Atrophy; Basal Ganglia/pathology; Brain/*pathology; Case Report; Cerebral Cortex/pathology; Creutzfeldt-Jakob Syndrome/diagnosis/genetics/*pathology; DNA Mutational Analysis; English Abstract; Female; Human; Middle Age; Nerve Degeneration/genetics/physiology; Neurologic Examination; Neuropsychological Tests; Prions/*analysis/genetics
AD Institut für Neuropathologie der Universität Göttingen.
SP deutsch
PO Deutschland