NR ABIC
AU Betmouni,S.; Perry,V.H.; Gordon,J.L.
TI Evidence for an early inflammatory response in the central nervous system of mice with scrapie
QU Neuroscience 1996 Sep; 74(1): 1-5
PT journal article
AB In Alzheimer's disease, the most prevalent of the neurodegenerative diseases, inflammation of the CNS contributes to the pathology and is a target for therapy.(13,18,19) In contrast, the group of neurodegenerative conditions known as the Prion Diseases have been widely reported as lacking any inflammatory elements(5,23) despite the many similarities between the pathologies of Alzheimer's Disease and Prion Diseases.(10) We have found evidence for an inflammatory component in mouse scrapie, characterized by microglial activation and T-lymphocyte recruitment, which appears long before any clinical signs of the disease and spreads along well-defined anatomical pathways. These observations emphasize the potential value of murine scrapie as a model for studying the inflammatory pathology of other neurodegenerative diseases.
IN Die Autoren meinen, in den Gehirnen von mit Scrapie infizierten Mäusen zu Beginn der Inkubationszeit Entzündungsreaktionen in Form von Mikrogliaaktivierung und T-Lymphozyten-Versammlung beobachtet zu haben.
ZR 30
MH Animal; Brain/*pathology; Central Nervous System/*pathology; Immunohistochemistry; Inflammation/*pathology; Mice; Mice, Inbred C57BL; Scrapie/*pathology; Time Factors
AD Department of Pharmacology, University of Oxford, U.K.
SP englisch
PO USA