NR ABBP
AU Bastian,F.O.
TI Spiroplasma-like inclusions in Creutzfeldt-Jakob disease
QU Archives of Pathology and Laboratory Medicine 1979 Dec; 103(13): 665-9
PT journal article
AB Spiral membranous inclusions were discovered on electron microscopic study of brain biopsy tissues from a 46-year-old man with Creutzfeldt-Jakob disease (CJD). These replicate coiled membranous configurations measured 850 to 1,000 nm in length and 75 to 137.5 nm in width and were located within axoplasm, primarily in presynaptic terminals. These inclusions closely resemble Spiroplasma, a plant pathogen, and the finding of these structures in CJD suggests the concurrence of Spiroplasma infection with a human chronic degenerative brain disease.
IN Elektronenmikroskopisch wurde bei einem 46 Jahre alten CJD-Patienten spiralige, membranöse Einschlüsse von 0,85-1 µm Länge und 75-137,5 nm Breite im Axoplasma und besonders in den Präsynapsen gefunden, welche den als Pflanzenpathogen bekannten Spiroplasmen ähneln.
MH Axons/*microbiology; Brain/*microbiology/pathology; Creutzfeldt-Jakob Syndrome/*microbiology/pathology; Cytoplasm/microbiology; Human; Male; Middle Age; Spiroplasma/*ultrastructure
SP englisch
PO USA