NR ABBH
AU Bassant,M.H.; Picard,M.; Olichon,D.; Cathala,F.; Court,L.
TI Changes in the serotonergic, noradrenergic and dopaminergic levels in the brain of scrapie-infected rats
QU Brain Research 1986 Mar 5; 367(1-2): 360-3
PT journal article
AB Levels of serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), dihydroxyphenylacetic acid (DOPAC) and 3,4-dihydroxyphenylethyleneglycol (DHPG) were determined by high-performance liquid chromatography in different brain areas of scrapie-infected rats, 8.5 months after intracerebral inoculation of a rat-adapted strain from mice brain (C 506). At this time, rats developed early clinical signs of the disease. Scrapie-infected rats showed a reduction in the levels of 5-HT and 5-HIAA (frontal cortex, hippocampus, mesolimbic structure). Concentrations of DHPG decreased in the frontal and parietal cortices but remained unchanged in the hippocampus. DOPAC levels decreased in the striatum but not in the mesolimbic structure. These results confirm that the serotonergic, noradrenergic and dopaminergic systems are altered in the brain of scrapie-infected rats. They can partly account for clinical signs of scrapie and are in agreement with the scarce data provided by the postmortem analysis of Creutzfeldt-Jakob disease brains.
IN 8,5 Monate nach intrazerebraler Inokulation mit Rattenscrapie traten die ersten Symptome auf. Gleichzeitig wurden verminderte Konzentrationen von Serotonin und dessen Harnausscheidungsproduktes 5-Hydroxyindolessigsäure in Stirnlappen, Hippocampus und mesolimbischen Strukturen gefunden. In der vorderen und seitlichen Hirnrinde, jedoch nicht im Hippocampus nahm die Konzentration von 3,4-Dihydroxyphenylethylenglycol ab. Die Konzentration von Dihydroxyphenylessigsäure nahm im Striatum, jedoch nicht in mesolimbischen Strukturen ab.
MH 3,4-Dihydroxyphenylacetic Acid/analysis; Animal; Biogenic Amines/*analysis; *Brain Chemistry; Dopamine/analysis; Hydroxyindoleacetic Acid/analysis; Male; Norepinephrine/analysis; Rats; Rats, Inbred Strains; Scrapie/*metabolism; Serotonin/analysis
SP englisch
PO Niederlande