NR AAXG
AU Baker,H.F.; Ridley,R.M.; Wells,G.A.H.
TI Experimental transmission of BSE and scrapie to the common marmoset
QU The Veterinary Record 1993 Apr 17; 132(16): 403-6
PT journal article
AB Two young male common marmosets (Callithrix jacchus) were injected intracerebrally and intraperitoneally with a crude brain homogenate prepared from a cow with bovine spongiform encephalopathy (BSE). Two other marmosets were similarly injected with brain homogenate from a sheep with natural scrapie. The two animals injected with scrapie material developed neurological signs 38 and 42 months after injection and the two animals injected with BSE material developed neurological signs after 46 and 47 months. Post mortem examination of the brains revealed spongiform encephalopathy especially in the basal nuclei and diencephalon of all the animals and, in addition, involvement of the cerebral cortex of the marmosets injected with scrapie material. The experiment extends the host range of experimental BSE to include a primate species.
IN Weißpinseläffchen aus der Gruppe der südamerikanischen Krallenaffen entwickelten BSE-typische Ausfälle 46-47 Monaten nach der Injektion von Gehirnhomogenat aus BSE-kranken Rindern oder 38 bzw. 42 Monate nach der Injektion von Gehirnhomogenat aus Scrapie-Schafen ins Gehirn oder die Bauchhöhle.
MH Animal; Brain/pathology; Callithrix/*microbiology; Encephalopathy, Bovine Spongiform/pathology/physiopathology/*transmission; Injections/veterinary; Injections, Intraperitoneal/veterinary; Male; Scrapie/pathology/physiopathology/*transmission; Spinal Cord/pathology; Time Factors; Tissue Extracts/administration & dosage
AD Division of Psychiatry, Clinical Research Centre, Harrow, Middlesex.
SP englisch
PO England