NR AAUU
AU Askanas,V.; Sarkozi,E.; Bilak,M.; Alvarez,R.B.; Engel,W.K.
TI Human muscle macrophages express beta-amyloid precursor and prion proteins and their mRNAs
QU Neuroreport 1995 May 9; 6(7): 1045-9
PT journal article
AB Well-characterized antibodies against beta-amyloid precursor protein (beta APP) and prion protein (PrP), and specific cRNA probes, were used to localize beta APP and PrP and their mRNAs in human muscle macrophages. Macrophages present in muscle biopsies of 51 patients with various neuromuscular disorders showed accumulation of beta APP and PrP, and strongly expressed beta APP and PrP mRNAs. These were present in all muscle macrophages unrelated to their localization within the muscle tissue or diagnosis. Our study provides the first demonstration that human muscle resident macrophages synthesize and accumulate beta APP and PrP. We suggest that those proteins play a role in biology of muscle macrophages, including their participation in inflammatory and immune responses.
IN Bei 51 PatientInnen mit verschiedenen neuromuskulären Störungen wurden Akkumulationen des beta-amyloid-Vorläuferproteins und des Prionproteins, sowie große Mengen ihrer mRNAs in den Muskelmakrophagen gefunden.
ZR 25 Zitate
MH Adolescent; Adult; Aged; Amyloid beta-Protein Precursor/*biosynthesis; Child; Female; Human; Immunohistochemistry; In Situ Hybridization; Macrophages/*metabolism; Male; Microscopy, Electron; Middle Age; Muscles/cytology/*metabolism; Prions/*biosynthesis; RNA Probes; RNA, Messenger/*biosynthesis; Support, Non-U.S. Gov't
AD Department of Neurology, University of Southern California School of Medicine, Los Angeles 90017, USA
SP englisch
PO England
OR Prion-Krankheiten 1