NR AATL
AU Arnold,S.E.; Trojanowski,J.Q.; Parchi,P.
TI Protease resistant prion proteins are not present in sporadic "poor outcome" schizophrenia
QU Journal of Neurology, Neurosurgery and Psychiatry 1999 Jan; 66(1): 90-2
IA http://jnnp.bmjjournals.com/cgi/content/full/66/1/90
PT journal article
AB Various clinical and epidemiological data have suggested the possibility of infectious mechanisms in schizophrenia. In addition, lengthy prodromal psychiatric symptoms can presage the development of Creutzfeldt-Jakob disease, a prototypical prion disorder. Accordingly, the presence of human protease resistant prion proteins (PrPres) was assessed in postmortem frontal cortical and thalamic tissues from a prospectively accrued and well characterised sample of elderly patients with chronic, sporadic, "poor outcome" schizophrenia using a sensitive immunoblot assay. No PrPres was found in the brains of any of the cases, providing evidence against a role for abnormal prion proteins in the pathogenesis of schizophrenia.
MH Aged; Aged, 80 and over; Brain/*enzymology; Comparative Study; Creutzfeldt-Jakob Syndrome/*enzymology; Endopeptidases/*metabolism; Female; Humans; Male; Prions/*metabolism; Prospective Studies; Psychiatric Status Rating Scales; Research Support, U.S. Gov't, P.H.S.; Schizophrenia/diagnosis/*enzymology; Schizophrenic Psychology
AD Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, USA. alveus@mail.med.upenn.edu
SP englisch
PO England