NR AAQE
AU Safar,J.G.; Prusiner,S.B.; DeArmond,S.J.
TI Diagnose und Pathogenese der Prionerkrankungen
QU Die gelben Hefte - Immunbiologische Informationen 3/1999; 39: 79-90
PT article
AB Human Creutzfeldt-Jakob disease and bovine spongiform encephalopathy are among the most prominent central nervous system degenerative disorders caused by prions. Human prion diseases may present as sporadic, genetic, or infectious illnesses. Prions are devoid of nucleic acid, seem to be composed exclusively of a modified protein (PrPsc), and replicate by an unprecedented conformational mechanism. Cellular prion protein (PrPc) is converted into PrPsc through a posttranslational process during which PrPc acquires a high ß-sheet content. There is now considerable concern that bovine prions may have been passed to humans. Within this context, the need for rapid, sensitive, and specific methods for detecting prions has become urgent.
SP deutsch
PO Deutschland