NR AAHA
AU Ando,S.; Toyoda,Y.; Nagai,Y.; Ikuta,F.
TI Alterations in brain gangliosides and other lipids of patients with Creutzfeldt-Jakob disease and subacute sclerosing panencephalitis (SSPE)
QU Japanese Journal of Experimental Medicine 1984 Dec; 54(6): 229-34
PT journal article
AB Lipid composition was examined with cerebral cortices of three cases of Creutzfeldt-Jakob (C-J) disease and one case of subacute sclerosing panencephalitis (SSPE). Phosphatidylethanolamine decreased in both C-J and SSPE brains. Sphingomyelin increased in CJ. The levels of cholesterol esters which occurred in a trace amount in normal control were elevated in C-J and more severely in SSPE. The total amounts of gangliosides were reduced in C-J and SSPE. Gangliosides GD1b, GT1b and GQ1b in the biosynthetic pathway B [23] specifically decreased in C-J, while GM1 and GD3 increased. An increased content of GD3 may be related to the proliferation of reactive astrocytes. A decrease of 22:6 (n-3) accompanied with an increase of oleic acid in the fatty acid composition of the acidic phospholipid fraction was observed. This might be a cause for alterations in membrane function.
MH Adult; Aged; Cerebral Cortex/*analysis; Child; Cholesterol/analysis; Comparative Study; Creutzfeldt-Jakob Syndrome/*metabolism; Fatty Acids/analysis; Female; Gangliosides/*deficiency; Human; Lipids/*analysis; Male; Middle Age; Phosphatidylethanolamines/analysis; Sphingomyelins/analysis; Subacute Sclerosing Panencephalitis/*metabolism
SP englisch
PO Japan