ZEFP.htm

NR ZEFP

AU Thurauf,N.; Friedel,I.; Hummel,C.; Kobal,G.

TI The mucosal potential elicited by noxious chemical stimuli with CO2 in rats: is it a peripheral nociceptive event?

QU Neuroscience Letters 1991 Jul 22; 128(2): 297-300

PT journal article

AB Negative mucosal potentials (NMPs) were recorded from the nasal respiratory mucosa in rats following retrograde stimulation with CO2 through a tube advanced to the nasopharynx. Local application of capsaicin (3 mg in 0.3 ml solvent, n = 5) and lidocaine (31 mg in 0.3 ml solvent, n = 5) eliminated the NMPs and cortical responses in the EEG. A quantitative reduction in NMPs was found following systemic pretreatment with capsaicin (cumulative dose, 200 mg/kg, n = 4), but not with guanethidine (50 mg/kg s.c., n = 4). Blood flow measurements and NMPs were obtained from the same recording position (n = 4). Onset of blood flow changes (1200-4800 ms) appeared significantly later than the onset of NMPs (120-500 ms). On the basis of these results a sensory neurogenic origin of the NMP is assumed.

AD Department of Pharmacology and Toxicology, University of Erlangen-Nuernberg, F.R.G.

SP englisch

PO Niederlande

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