NR ZDKW

AU Grubb,B.; Mills,C.D.; Colacino,J.M.; Schmidt-Nielsen,K.

TI Effect of arterial carbon dioxide on cerebral blood flow in ducks

QU American Journal of Physiology 1977 Jun; 232(6): H596-601

PT journal article

AB The purpose of this study was to determine the effect of arterial PCO2 on blood flow to the avian brain. Cerebral blood flow was measured on curarized, artificially ventilated Pekin ducks by the rate at which intra-arterially injected xenon-133 was cleared from the duck's brain. A two-component clearance curve resulted: the blood flow calculated from the fast and slow components was similar to the blood flow to mammalian grey and white matter, respectively. Hypercapnia markedly increased the fast component of blood flow, whereas hypocapnia had no effect on this component. These effects were not due to changes in blood pressure, which was independent of arterial PCO2. Blood flow calculated from the slow component was independent of arterial PCO2. We conclude that the lack of response to hypocapnia may contribute to the exceptional tolerance of birds to high altitude by maintaining normal cerebral blood flow.

SP englisch

PO USA

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