NR ZCVB

AU Waser,P.G.; Ganz,A.J.; Pfirrmann,R.W.

TI [Development of new antiepileptics. II. Anticonvulsant effect of hydantoin derivatives]

OT Die Entwicklungen neuer Antiepileptika. Teil II: Antikonvulsive Wirkung einiger Hydantoin-Derivate.

QU Arzneimittel-Forschung 1977; 27(11): 2125-8

PT journal article

AB From a series of N-substituted hydantoin derivatives, 1-phenyl-3-(o-chloro-p-sulfonamide-phenyl)-hydantoin was found to exhibit the best anticonvulsant activity against electroshock seizures. This substance showed also a weak activity against pentylenetetrazole seizures, as well as minor analgesic and sedative effects. The toxic effects are negligible; the lethal dose in mice was higher than 5000 mg/kg p.o. The other tested hydantoin derivatives showed much weaker anticonvulsant activities.

SP deutsch

PO Westdeutschland

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