ZCVA.htm

NR ZCVA

AU Waser,P.G.; Ganz,A.J.; Pfirrmann,R.W.

TI [Development of new antiepileptic agents. III. Anticonvulsant activity of some derivatives of 1-(p-sulfamoylphenyl)-imidazolidinone-5 (author's transl)]

OT Die Entwicklung neuer Antiepileptika. III. Antikonvulsive Wirkung einiger 1-(p-Sulfamoylphenyl)-imidazolidinon-5-Derivate).

QU Arzneimittel-Forschung 1977; 27(12): 2336-41

PT journal article

AB A series of derivatives of 1-(p-sulfamoylphenyl)imidazolidinone-5 were tested for anticonvulsant properties against electroshock and pentylenetetrazole seizures. They were also screened for analgesic, sedative and toxic effects. The substances that had the best anticonvulsant activities were those with halogen substitution in the ortho position of the 1-phenylring of 1-(p-sulfamoylphenyl)-3-phenylimidazolidinone-5. Additional substitutions on the basic structure (imidazolidinone-5) or on the 3-phenylring diminished the anticonvulsant activity. The anticonvulsants are less toxic than diphenylhydantoin. Some of the substances exhibited feeble analgesic and sedative properties.

SP deutsch

PO Westdeutschland

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