NR ZCUR

AU Verma,A.; Hirsch,D.J.; Glatt,C.E.; Ronnett,G.V.; Snyder,S.H.

TI Carbon monoxide: a putative neural messenger.

QU Science 1993 Jan 15; 259(5093): 381-4

KI Science. 1993 Jan 15;259(5093):309. PMID: 8093563

ER Science 1994 Jan 7;263(5143):15

PT journal article

AB Carbon monoxide, an activator of guanylyl cyclase, is formed by the action of the enzyme heme oxygenase. By in situ hybridization in brain slices, discrete neuronal localization of messenger RNA for the constitutive form of heme oxygenase throughout the brain has been demonstrated. This localization is essentially the same as that for soluble guanylyl cyclase messenger RNA. In primary cultures of olfactory neurons, zinc protoporphyrin-9, a potent selective inhibitor of heme oxygenase, depletes endogenous guanosine 3',5'-monophosphate (cGMP). Thus, carbon monoxide, like nitric oxide, may be a physiologic regulator of cGMP. These findings, together with the neuronal localizations of heme oxygenase, suggest that carbon monoxide may function as a neurotransmitter.

AD Department of Neurology, Walter Reed Army Medical Center, Washington, DC 20307.

SP englisch

PO USA

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