ZCAF.htm

NR ZCAF

AU Gregory,N.G.; Wilkins,L.J.

TI The intravenous halothane test as an experimental method for quantifying stress sensitivity in pigs

QU Journal of the Science of Food and Agriculture 1984 Feb; 35(2): 147-53

PT journal article

AB The venous blood pH, pCO2, lactate, pyruvate and haematocrit responses to an intravenous (i/v) infusion of halothane-lipid emulsion were assessed in Pietrain, Pietrain x Norwegian Landrace and Gloucester pigs. Halothane-induced lactacidosis was dose related in the Pietrain (stress sensitive) pigs between 0 and 82 myl halothane kg(xp=minus1), whereas the crossbred and Gloucester pigs did not show any lactacidosis. It is concluded that the i/v halothane test can be used to quantify a stress sensitive pig's reaction to the drug, and that the crossbred pig does not express halothane sensitivity even at a mild level. Carazolol pretreatment in Pietrain pigs increased the halothane-induced lactacidosis, whereas in a separate study carazolol was found to decrease their rate of post-mortem muscle acidification. This indicates that halothane activates a different mechanism from stress when inducing lactacidosis in stress sensitive pigs.

SP englisch

PO England

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