NR ZBDT

AU Strain,G.M.; Olcott,B.M.; Turk,M.A.

TI Diagnosis of primary generalized epilepsy in a cow

QU Journal of the American Veterinary Medical Association 1987 Oct 1; 191(7): 833-6

PT journal article

AB On the basis of history, electrodiagnostic and neuropharmacologic studies, and results of laboratory testing and necropsy, a seizure disorder of 1.5 years' duration in an 8-year-old Hereford cow was diagnosed as primary generalized epilepsy. Evidence of metabolic, toxicologic, head trauma, or genetic cause of the seizures was not found. A morphologic cause for the convulsions also was not detected. One naturally occurring seizure was recorded electroencephalographically, but interictal EEG abnormalities were not seen. Attempts to evoke a seizure with photostimulation or therapeutic doses of acepromazine, ketamine, tripelennamine, and estradiol cypionate were unsuccessful. The seizure threshold for the CNS stimulant pentylenetetrazol was found to be less than 6 mg/kg, IV; the seizure threshold in a control cow was found to be greater than 12 mg/kg, IV. The pharmacologic protocol used for this cow may be useful for diagnosis of epilepsy in other animals.

AD Department of Veterinary Physiology, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803.

SP englisch

PO USA

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