ZBCP.htm

NR ZBCP

AU Shaw,N.A.

TI The effects of electroconvulsive shock on the flash visual evoked potential in the rat

QU Electroencephalography and Clinical Neurophysiology 1997 Mar; 104(2): 180-7

PT journal article

AB The effects of electroconvulsive shock (ECS) on the flash visual evoked potential (FVEP) were studied in the awake albino rat. Immediately after the induction of generalised seizure activity, the FVEP was totally abolished although accidentally averaged rhythmic epileptiform activity was often present in the trace. During the second recording, a potential had reappeared but this response was suspected of being a superior colliculus FVEP masquerading as a cortical response. By the third recording, the genuine cortical FVEP had returned, albert with an abnormally large amplitude. The waveform subsequently remained significantly distorted although it had regained an approximately normal morphology within 6-7 min of the administration of ECS. It was not possible to identify the principal site of action of ECS but it was concluded that ECS may impact on activity generated at more than one location within the optic pathways. The present findings are compared with a number of previous animal and human studies where the FVEP was apparently preserved following ECS and attempts are made to explain the discrepancy in results. The relevance of the present findings for understanding the pathophysiology of electrical stunning and of the loss or impairment of consciousness during generalised epileptic seizures is also discussed.

AD Department of Physiology, School of Medicine, University of Auckland, New Zealand.

SP englisch

PO Irland

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