ZAVQ.htm

NR ZAVQ

AU Morris,J.P.; Ong,R.M.; O'Dwyer,J.K.; Barnett,J.L.; Hemsworth,P.H.; Clarke,I.J.; Jongman,E.C.

TI Pain-related cerebral potentials in response to acute painful electrical stimulation in sheep

QU Australian Veterinary Journal 1997 Dec; 75(12): 883-6

PT journal article

AB OBJECTIVE: To examine associations between late event-related cerebral potential amplitudes and behavioural responses to noxious electrical stimulation as an indicator of acute pain in sheep. DESIGN: Analysis of variance for the effects of stimulus intensity on the behaviour and event-related cerebral potential variables. PROCEDURE: Ninety-six brief constant current electrical pulse trains were presented to the front left leg of eight sheep at four intensities (2.5 to 10 mA) in a randomised order. An event-related cerebral potential and a graded flinch response were recorded for each stimulus and the 24 event-related cerebral potentials at each intensity were averaged to produce a mean waveform. Various components of this waveform were analysed and changes in these measures and the sheep's flinch response, as stimulus intensity increased, were determined. RESULTS: Both the flinch response and some event-related cerebral potential components, that is, peak amplitudes 114 [N1], 187 [P1], 318 [P2] and 230 [Pm] ms after stimulus onset, were significantly affected as stimulus intensity increased. CONCLUSION: These corresponding behavioural and event-related cerebral potential changes indicate the usefulness of using changes in the event-related cerebral potential to measure acute pain in sheep.

AD Victorian Institute of Animal Science, Werribee.

SP englisch

PO Australien

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