ZATC.htm

NR ZATC

AU Linstedt,U.; Link,J.; Grabener,M.; Kloess,W.

TI Effects of selective angiography of the carotid artery with carbon dioxide on electroencephalogram somatosensory evoked potentials and histopathologic findings. A pilot study in pigs.

QU Investigative Radiology 1997 Sep; 32(9): 507-10

PT journal article

AB RATIONALE AND OBJECTIVES: The authors investigate the cerebral effects of selective carotid angiography with carbon dioxide (CO2). METHODS: In 6 pigs, CO2 was injected into the carotid artery with consecutively increasing doses. Cerebral function was monitored with two-channel electroencephalography and somatosensory evoked potentials (SEPs). After the experiment the brains were investigated histopathologically. RESULTS: Initial doses led to reversible decreases in electroencephalograph power by 40% to 80%. Further doses result in partly nonreversible electroencephalographic changes. Somatosensory evoked potential latencies (n = 5) were not changed. Amplitudes were not affected in low dose ranges up to 40 mL CO2. Higher CO2 doses led to different changes. There were no SEP amplitude reductions (n = 1), as well as reversible (n = 2) and nonreversible (n = 2) SEP amplitude reductions. Histopathologically, edema (n = 6), edema necrosis (n = 2), and destroyed cells as a sign of ischemia (n = 2) were found. CONCLUSIONS: Administering CO2 in brain supplying arteries impairs the cerebral function. Consecutive, increasing doses lead to partly nonreversible electroencephalographic and SEP changes and brain tissue damages.

AD Clinic of Anesthesiology, Christian-Albrechts-University of Kiel, Germany. ulf.linstedt@rd.comcity.de

SP englisch

PO USA

Autorenindex - authors index
Startseite Betäubung - home page Stunning